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Michael Chin

MICHAEL T. CHIN M.D., Ph.D., F.A.C.C., F.A.H.A.​

Associate Professor of Medicine 
Harold T. Dodge/John L. Locke Endowed Chair of Cardiovascular Medicine
 
UW Research - South Lake Union Complex 
850 Republican Street 
Box 358050 
Seattle, WA 98109​
 
 
 
 
 

EDUCATION AND TRAINING

  • Cardiology Fellow, Brigham and Women's Hospital, Boston, MA, 1994-1997
  • Postdoctoral Fellow, National Institute on Aging, Baltimore, MD, 1993-1994
  • Residency in Internal Medicine, The Johns Hopkins Hospital, Baltimore, MD, 1991-1993
  • M.D. (with Honors), University of Rochester, Rochester, NY, 1991
  • Ph.D., University of Rochester, Rochester, NY, 1988
  • A.B., Princeton University, Princeton, NJ, 1983

 

BOARD CERTIFICATION

  • American Board of Internal Medicine, 1997
 

AREAS OF CLINICAL EXPERTISE

  • General Cardiology
  • Role of Smooth Muscle Cells in Occlusive Vascular Disease
  • Regulation of Cardiac Hypertrophy and Heart Failure


SPECIAL ACCOMPLISHMENTS

  • Harold T. Dodge/John L. Locke Endowed Chair in Cardiovascular Medicine, 2006
  • Fellow, American Heart Association, 2004
  • Fellow, American College of Cardiology, 2002
  • Finalist, Katz Young Investigator Competition, American Heart Association, 2002
  • 1st Prize, AstraZeneca Cardiovascular Young Investigator's Forum, 2002
  • 2nd Prize, New England Cardiovascular Research Competition, 2000
  • 1st Prize, American College of Cardiology Young Investigator Competition, 2000
  • Research Award for Clinical Trainees, National Institutes of Health, 1992
  • Class of 1976 Prize, University of Rochester, 1991
  • Robert Kates Award, University of Rochester, 1991
  • Wallace O. Fenn Award, University of Rochester, 1991
  • Walter R. Bloor Award, Universtiy of Rochester, 1989

CURRENT RESEARCH INTERESTS

 
 

 Selected Publications

 
 
Dai DF, Hsieh EJ, Liu Y, Chen T, Beyer RP, Chin MT, MacCoss MJ, Rabinovitch PS "Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress." Cardiovascular research 2012 Jan; 93; 1; 79-88
 
 
Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT, Stolz DB, Davis EC, Dichek DA "Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis." Arteriosclerosis, thrombosis, and vascular biology 2012 Jan; 32; 1; e1-11
 
 
Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS "Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure." Circulation research 2011 Apr; 108; 7; 837-46
 
 
Wu L, Chien WM, Hartman ME, Moussavi-Harami F, Liu Y, Chin MT "Regulation of MMP10 expression by the transcription factor CHF1/Hey2 is mediated by multiple E boxes." Biochemical and biophysical research communications 2011 Dec; 415; 4; 662-8
 
 
Watanabe T, Koibuchi N, Chin MT "Transcription factor CHF1/Hey2 regulates coronary vascular maturation." Mechanisms of development 2010 Sep-Dec ; 127; 9-12; 418-27
 
 
Liu Y, Yu M, Wu L, Chin MT "The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload." American journal of physiology. Heart and circulatory physiology 2010 Jun; 298; 6; H2082-92
 
 
Yu M, Xiang F, Beyer RP, Farin FM, Bammler TK, Chin MT "Transcription Factor CHF1/Hey2 Regulates Specific Pathways in Serum Stimulated Primary Cardiac Myocytes: Implications for Cardiac Hypertrophy." Current genomics 2010 Jun; 11; 4; 287-96
 
 
Yu M, Liu Y, Xiang F, Li Y, Cullen D, Liao R, Beyer RP, Bammler TK, Chin MT "CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload through selective repression and activation of specific transcriptional pathways." Omics : a journal of integrative biology 2009 Dec; 13; 6; 501-11