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Kevin O'Brien

KEVIN D. O'BRIEN, MD, FAHA

Professor of Medicine
Attending Physician, University of Washington Medical Center
 
University of Washington Medical Center
1959 N.E. Pacific Street
Box 356422
Seattle, WA 98195-6422
 
 
 
 
 

EDUCATION AND TRAINING

  • Senior Cardiology Fellow, University of Washington, Seattle, WA, 1992
  • Senior Research Fellow, Metabolism, Endocrinology, Nutrition, University of Washington, Seattle, WA, 1989
  • Chief Medical Resident, Veterans' Affairs Medical Center, Seattle, WA, 1988
  • Internship and Residency, University of Washington, Seattle, WA, 1987
  • MD, (with honor in Medicine and Thesis Honors), University of Washington, Seattle, WA, 1984
  • Medical Student Research Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA, 1981
  • BS, (summa cum laude), University of Idaho, Moscow, ID, 1980
   
 

BOARD CERTIFICATION

  • American Board of Internal Medicine, Cardiovascular Diseases, 1991, 2002
  • American Board of Internal Medicine, 1987

 

 AREAS OF CLINICAL ​EXPERTISE

  • Congestive Heart Failure and Cardiac Transplantation
  • Lipid Disorders
  

 

SPECIAL ACCOMPLISHMENTS

 

  • President-Elect, Western Society for Clinical Investigation, 2006–2007
  • Outstanding Investigator, Western Society for Clinical Investigation, 2003
  • President, American Federation for Medical Research, 2001–2002
  • Sheard-Sanford Award, American Society of Clinical Pathologists, 1983
  • Robert L. Van Citters Medical Thesis Award, University of Washington, 1982
  • Phi Beta Kappa, Buchanan Award (Perfect Undergraduate G.P.A.), Theophilus Award (The University's Most Outstanding Graduate), University of Idaho, 1980
     

CURRENT RESEARCH INTERESTS​

 

 Selected Publications

 
 
Thanassoulis G*, Campbell CY*, Owens DS*, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, Malhotra R, O’Brien KD, Allison MA, Aspelund T, Criqui MH,. Heckbert SH, Hwang S-J, Liu Y, Sjogren M, van der Pals J, Kälsch H, Mühleisen TW, Nöthen MM, Cupples LA, Caslake M, Di Angelantonio E, Danesh J, Rotter JI, Sigurdsson S, Wong Q, Erbel R, Kathiresan S, Melander O, Gudnason V*, O’Donnell CJ*, Post WS* for the CHARGE Extracoronary Calcium Working Group. A genomewide study of valvular calcification and aortic stenosis. N Engl J Med (In Press), 2012.
 
 
Umemoto U, Subramanian S, Ding Y, Goodspeed L, Wang S, Han C-Y, Sta Teresa A, Kim J, O’Brien KD, Chait A. Ezetimibe inhibits atherosclerosis without reducing adipose tissue inflammation in obese cholesterol-fed LDL receptor deficient mice. J Lipid Res 53(11):2380-2389, 2012.
 
 
Osman N, Grande-Allen KJ, Ballinger ML, Getachew R, Marasco S, O’Brien KD, Little PJ. Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells and enhances binding of LDL to proteoglycans. Cardiovasc Pathol (Epub 20 Sept 2012), 2012.
 
 
Ding Y, Subramanian S, Goodpseed L, Wang S, Han C-Y, Sta Teresa A, Kim J, O’Brien KD, Chait A. Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against adipose tissue inflammation induced by a high-fat, high-carbohydrate diet in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 32(7):1596-1604, 2012.
 
 
Elmariah S, Delaney JAC, Bluemke DA, Budoff MJ, O’Brien KD, Fuster V, Kronmal RA, Halperin JL. Associations of left ventricular hypertrophy with prevalent and incident valve calcification: The Multi-Ethnic Study of Atherosclerosis. J Am Col Cardiol Img 5:781-788, 2012.
 
 
Owens DS, Budoff MJ, Katz R, Takasu J, Shavelle DM, Carr JJ, Heckbert SR, Otto CM, Probstfield JL, Kronmal R, O’Brien KD. Aortic valve calcium as a predictor of primary cardiovascular events in the Multi-Ethnic Study of Atherosclerosis. J Am Col Cardiol Img 5:619-625, 2012.
 
 
Chang MY, Chan CK, Braun KR, Green PS, O’Brien KD, Chait A, Day AJ, Wight TN. Monocyte to macrophage differentiation: Synthesis and secretion of a complex extracellular matrix. J Biol Chem 287(17):14122-14135, 2012.
 
 
Paramsothy P, Katz R, Owens DS, Burke GL, Probstfield JL, O’Brien KD. Age modification of the association of lipoprotein, lipid and lipoprotein ratio with carotid intima-media thickness (from the Multi-Ethnic Study of Atherosclerosis [MESA]. Am J Cardiol, 109(5):658-664, 2012.