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Kevin O'Brien


Professor of Medicine
Attending Physician, University of Washington Medical Center
University of Washington Medical Center
1959 N.E. Pacific Street
Box 356422
Seattle, WA 98195-6422


  • Senior Cardiology Fellow, University of Washington, Seattle, WA, 1989–1992
  • Senior Research Fellow, Metabolism, Endocrinology, Nutrition, University of Washington, Seattle, WA, 1988–1989
  • Chief Medical Resident, Veterans' Affairs Medical Center, Seattle, WA, 1987–1988
  • Internship and Residency, University of Washington, Seattle, WA, 1984–1987
  • M.D. (with Honor in Medicine and Thesis Honors), University of Washington, Seattle, WA, 1984
  • Medical Student Research Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA, 1981
  • B.S. (Summa Cum Laude), University of Idaho, Moscow, ID, 1980


  • ABIM, Cardiovascular Diseases, 1991, 2002
  • American Board of Internal Medicine, 1987



  • Congestive heart failure and cardiac transplantation
  • Lipid disorders


  • President-Elect, Western Society for Clinical Investigation, 2006–2007
  • Outstanding Investigator, Western Society for Clinical Investigation, 2003
  • President, American Federation for Medical Research, 2001–2002
  • Sheard-Sanford Award, American Society of Clinical Pathologists, 1983
  • Robert L. Van Citters Medical Thesis Award, University of Washington, 1982
  • Phi Beta Kappa, Buchanan Award (Perfect Undergraduate G.P.A.), Theophilus Award (The University's Most Outstanding Graduate), University of Idaho, 1980



 Selected Publications

Thanassoulis G*, Campbell CY*, Owens DS*, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, Malhotra R, O’Brien KD, Allison MA, Aspelund T, Criqui MH,. Heckbert SH, Hwang S-J, Liu Y, Sjogren M, van der Pals J, Kälsch H, Mühleisen TW, Nöthen MM, Cupples LA, Caslake M, Di Angelantonio E, Danesh J, Rotter JI, Sigurdsson S, Wong Q, Erbel R, Kathiresan S, Melander O, Gudnason V*, O’Donnell CJ*, Post WS* for the CHARGE Extracoronary Calcium Working Group. A genomewide study of valvular calcification and aortic stenosis. N Engl J Med (In Press), 2012.
Umemoto U, Subramanian S, Ding Y, Goodspeed L, Wang S, Han C-Y, Sta Teresa A, Kim J, O’Brien KD, Chait A. Ezetimibe inhibits atherosclerosis without reducing adipose tissue inflammation in obese cholesterol-fed LDL receptor deficient mice. J Lipid Res 53(11):2380-2389, 2012.
Osman N, Grande-Allen KJ, Ballinger ML, Getachew R, Marasco S, O’Brien KD, Little PJ. Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells and enhances binding of LDL to proteoglycans. Cardiovasc Pathol (Epub 20 Sept 2012), 2012.
Ding Y, Subramanian S, Goodpseed L, Wang S, Han C-Y, Sta Teresa A, Kim J, O’Brien KD, Chait A. Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against adipose tissue inflammation induced by a high-fat, high-carbohydrate diet in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 32(7):1596-1604, 2012.
Elmariah S, Delaney JAC, Bluemke DA, Budoff MJ, O’Brien KD, Fuster V, Kronmal RA, Halperin JL. Associations of left ventricular hypertrophy with prevalent and incident valve calcification: The Multi-Ethnic Study of Atherosclerosis. J Am Col Cardiol Img 5:781-788, 2012.
Owens DS, Budoff MJ, Katz R, Takasu J, Shavelle DM, Carr JJ, Heckbert SR, Otto CM, Probstfield JL, Kronmal R, O’Brien KD. Aortic valve calcium as a predictor of primary cardiovascular events in the Multi-Ethnic Study of Atherosclerosis. J Am Col Cardiol Img 5:619-625, 2012.
Chang MY, Chan CK, Braun KR, Green PS, O’Brien KD, Chait A, Day AJ, Wight TN. Monocyte to macrophage differentiation: Synthesis and secretion of a complex extracellular matrix. J Biol Chem 287(17):14122-14135, 2012.
Paramsothy P, Katz R, Owens DS, Burke GL, Probstfield JL, O’Brien KD. Age modification of the association of lipoprotein, lipid and lipoprotein ratio with carotid intima-media thickness (from the Multi-Ethnic Study of Atherosclerosis [MESA]. Am J Cardiol, 109(5):658-664, 2012.
van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O’Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting macrophage emigration from plaques. Nature Immunol 13(2):136-143, 2012. 10. The AIM-HIGH Investigators. Niacin use in cardiovascular patients receiving intensive statin therapy. N Engl J Med 365(24):2255-2267, 2011.
Handa P, Tateya S, Rizzo NO, Cheng AM, Morgan-Stevenson V, Han C-Y, Clowes AW, Daum G, O’Brien KD, Schwartz MW, Chait A, Kim F. Role of vascular nitric oxide-cGMP signaling in adipose tissue inflammation during high-fat feeding. Arterioscler Thromb Vasc Biol 31(12):2827-2835, 2011.
Rajamannan NM, Evans F, Aikawa E, Grande-Allen KJ, Demer L, Heistad D, Simmons C, Masters K, Mathieu P, O’Brien KD, Schoen F, Towler D, Yoganathan A, Otto CM. Calcific aortic valve disease: Not simply a degenerative process. A review and agenda for research from the National Heart Lung and Blood Institute Aortic Stenosis Working Group. Circulation 124(16):1783-1791, 2011.
Subramanian S, Goodspeed L, Wang S, Kim J, Ioannou G, Haigh G, Yeh MM, Kowdley KV, O’Brien KD, Chait A. Dietary cholesterol alters the hepatic steatosis phenotype in obese LDL receptor-deficient mice. J Lipid Res 52(9):1626-35, 2011.
Paik J, Fierce Y, Mai PO, Phelps SR, McDonald T, Treuting P, Drivdahl R, Brabb T, Leboeuf R, O'Brien KD, Maggio-Price L. Murine norovirus increased atherosclerotic lesion size and inflammation in Ldlr-/- mice. Comp Med 61(4):330-338, 2011.
Linefsky JP, O’Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Siscovick DS, Kestenbaum B. Association of serum phosphate levels with aortic valve sclerosis and annular calcification in older adults: the Cardiovascular Health Study. J Am Coll Cardiol 58(3):291-297, 2011.
Yoon J, Subramanian S, Ding Y, Wang S, Goodspeed L, Sullivan B, O’Brien KD, Chait, A. Chronic insulin therapy reduces adipose tissue macrophage content but does not improve systemic inflammation in LDL receptor-deficient mice (Epub 17 Feb). Diabetologia, 54(5):1252-1260, 2011.